Science seeks to answer questions about ourselves and the world around us. Many times, the most important discoveries are completely unexpected – like when a moldy dish left out during vacation leads to the discovery of a vital medicine, penicillin! But, if something is unexpected, how can we prepare for positive and/or negative outcomes? When it comes to understanding the brain, enter: Neuroethics! Careful scientists must consider ethics during their research, including preparing for unanticipated consequences of exciting scientific advances. This challenge sought creative essays or videos from currently enrolled U.S. high school students that describe a teen’s perspective on the ethics, limitations, and implications of emerging technology to study and treat disorders of the human brain. https://www.challenge.gov/challenge/brain-initiative-challenge/